10.1184/R1/6096938.v1
Bozhi Tian
Bozhi
Tian
Itzhaq Cohen-Karni
Itzhaq
Cohen-Karni
Quan Qing
Quan
Qing
Xiaojie Duan
Xiaojie
Duan
Ping Xie
Ping
Xie
Charles M. Lieber
Charles M.
Lieber
Three-dimensional, flexible nanoscale field-effect transistors as localized bioprobes.
Carnegie Mellon University
2010
Animals
Biosensing Techniques
Cell Line
Cells
Cultured
Chick Embryo
Electric Conductivity
Electrophysiological Phenomena
Equipment Design
Hydrogen-Ion Concentration
Lipid Bilayers
Membrane Potentials
Mice
Microfluidics
Myocytes
Cardiac
Nanowires
Sensitivity and Specificity
Sodium Chloride
Transistors
Electronic
2010-08-13 00:00:00
Journal contribution
https://kilthub.cmu.edu/articles/journal_contribution/Three-dimensional_flexible_nanoscale_field-effect_transistors_as_localized_bioprobes_/6096938
<p>Nanoelectronic devices offer substantial potential for interrogating biological systems, although nearly all work has focused on planar device designs. We have overcome this limitation through synthetic integration of a nanoscale field-effect transistor (nanoFET) device at the tip of an acute-angle kinked silicon nanowire, where nanoscale connections are made by the arms of the kinked nanostructure, and remote multilayer interconnects allow three-dimensional (3D) probe presentation. The acute-angle probe geometry was designed and synthesized by controlling cis versus trans crystal conformations between adjacent kinks, and the nanoFET was localized through modulation doping. 3D nanoFET probes exhibited conductance and sensitivity in aqueous solution, independent of large mechanical deflections, and demonstrated high pH sensitivity. Additionally, 3D nanoprobes modified with phospholipid bilayers can enter single cells to allow robust recording of intracellular potentials.</p>