10.1184/R1/6097397.v1
Jaime Cuevas Tabares
Jaime Cuevas
Tabares
Robert MacLachlan
Robert
MacLachlan
Charles A. Ettensohn
Charles A.
Ettensohn
Cameron N. Riviere
Cameron N.
Riviere
Cell micromanipulation with an active handheld micromanipulator.
Carnegie Mellon University
2010
Equipment Design
Equipment and Supplies
Miniaturization
2010-01-01 00:00:00
Journal contribution
https://kilthub.cmu.edu/articles/journal_contribution/Cell_micromanipulation_with_an_active_handheld_micromanipulator_/6097397
<p>The paper describes the use of an active handheld micromanipulator, known as Micron, for micromanipulation of cells. The device enables users to manipulate objects on the order of tens of microns in size, with the natural ease of use of a fully handheld tool. Micron senses its own position using a purpose-built microscale optical tracker, estimates the erroneous or undesired component of hand motion, and actively corrects it by deflecting its own tool tip using piezoelectric actuators. Benchtop experiments in tip positioning show that active compensation can reduce positioning error by up to 51% compared to unaided performance. Preliminary experiments in bisection of sea urchin embryos exhibit an increased success rate when performed with the help of Micron.</p>