%0 Journal Article %A Manole, Mioara D. %A Foley, Lesley %A Hitchens, T. Kevin %A Kochanek, Patrick M. %A Hickey, Robert W. %A Bayir, Hulya %A Alexander, Henry %A Ho, Chien %A Clark, Robert S. B. %D 2009 %T Magnetic resonance imaging assessment of regional cerebral blood flow after asphyxial cardiac arrest in immature rats. %U https://kilthub.cmu.edu/articles/journal_contribution/Magnetic_resonance_imaging_assessment_of_regional_cerebral_blood_flow_after_asphyxial_cardiac_arrest_in_immature_rats_/6103646 %R 10.1184/R1/6103646.v1 %2 http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18827831/ %K Aging %K Animals %K Asphyxia %K Blood Pressure %K Blood-Brain Barrier %K Body Weight %K Cerebrovascular Circulation %K Heart Arrest %K Magnetic Resonance Imaging %K Rats %K Sprague-Dawley %X

Cerebral blood flow (CBF) alterations after asphyxial cardiac arrest (CA) are not defined in developmental animal models or humans. We characterized regional and temporal changes in CBF from 5 to 150 mins after asphyxial CA of increasing duration (8.5, 9, 12 min) in postnatal day (PND) 17 rats using the noninvasive method of arterial spin-labeled magnetic resonance imaging (ASL-MRI). We also assessed blood-brain barrier (BBB) permeability, and evaluated the relationship between CBF and mean arterial pressure after resuscitation. After all durations of asphyxia CBF alterations were region dependent. After 8.5- and 9-min asphyxia, intense subcortical hyperemia at 5 min was followed by return of CBF to baseline values by 10 mins. After 12-min asphyxia, hyperemia was absent and hypoperfusion reached a nadir of 38% to 65% of baselines with the lowest values in the cortex. BBB was impermeable to gadoteridol 150 mins after CA. CBF in the 12-min CA group was blood pressure passive at 60 min assessed via infusion of epinephrine. ASL-MRI assessment of CBF after asphyxial CA in PND 17 rats reveals marked duration and region-specific reperfusion patterns and identifies possible new therapeutic targets.

%I Carnegie Mellon University