10.1184/R1/6103835.v1 Lesley Foley Lesley Foley Alia M. Iqbal O'Meara Alia M. Iqbal O'Meara Stephen R. Wisniewski Stephen R. Wisniewski T. Kevin Hitchens T. Kevin Hitchens John A. Melick John A. Melick Chien Ho Chien Ho Larry W. Jenkins Larry W. Jenkins Patrick M. Kochanek Patrick M. Kochanek MRI assessment of cerebral blood flow after experimental traumatic brain injury combined with hemorrhagic shock in mice. Carnegie Mellon University 2013 Animals Blast Injuries Blood Gas Analysis Blood Pressure Brain Injuries Carbon Dioxide Cerebrovascular Circulation Disease Models Animal Image Interpretation Computer-Assisted Magnetic Resonance Imaging Male Mice Inbred C57BL Oxygen Resuscitation Shock Hemorrhagic Time Factors 2013-01-01 00:00:00 Journal contribution https://kilthub.cmu.edu/articles/journal_contribution/MRI_assessment_of_cerebral_blood_flow_after_experimental_traumatic_brain_injury_combined_with_hemorrhagic_shock_in_mice_/6103835 <p>Secondary insults such as hypotension or hemorrhagic shock (HS) can greatly worsen outcome after traumatic brain injury (TBI). We recently developed a mouse combined injury model of TBI and HS using a controlled cortical impact (CCI) model and showed that 90 minutes of HS can exacerbate neuronal death in hippocampus beneath the contusion. This combined injury model has three clinically relevant phases, a shock, pre hospital, and definitive care phases. Mice were randomly assigned to four groups, shams as well as a CCI only, an HS only, and a CCI+HS groups. The CCI and HS reduced cerebral blood flow (CBF) in multiple regions of interest (ROIs) in the hemisphere ipsilateral and contralateral to injury. Hemorrhagic shock to a level of ∼30 mm Hg exacerbated the CCI-induced CBF reductions in multiple ROIs ipsilateral to injury (hemisphere and thalamus) and in the hemisphere contralateral to injury (hemisphere, thalamus, hippocampus, and cortex, all P</p>