10.1184/R1/6103835.v1
Lesley Foley
Lesley
Foley
Alia M. Iqbal O'Meara
Alia M. Iqbal
O'Meara
Stephen R. Wisniewski
Stephen
R. Wisniewski
T. Kevin Hitchens
T. Kevin
Hitchens
John A. Melick
John A.
Melick
Chien Ho
Chien
Ho
Larry W. Jenkins
Larry W.
Jenkins
Patrick M. Kochanek
Patrick M.
Kochanek
MRI assessment of cerebral blood flow after experimental traumatic brain injury combined with hemorrhagic shock in mice.
Carnegie Mellon University
2013
Animals
Blast Injuries
Blood Gas Analysis
Blood Pressure
Brain Injuries
Carbon Dioxide
Cerebrovascular Circulation
Disease Models
Animal
Image Interpretation
Computer-Assisted
Magnetic Resonance Imaging
Male
Mice
Inbred C57BL
Oxygen
Resuscitation
Shock
Hemorrhagic
Time Factors
2013-01-01 00:00:00
Journal contribution
https://kilthub.cmu.edu/articles/journal_contribution/MRI_assessment_of_cerebral_blood_flow_after_experimental_traumatic_brain_injury_combined_with_hemorrhagic_shock_in_mice_/6103835
<p>Secondary insults such as hypotension or hemorrhagic shock (HS) can greatly worsen outcome after traumatic brain injury (TBI). We recently developed a mouse combined injury model of TBI and HS using a controlled cortical impact (CCI) model and showed that 90 minutes of HS can exacerbate neuronal death in hippocampus beneath the contusion. This combined injury model has three clinically relevant phases, a shock, pre hospital, and definitive care phases. Mice were randomly assigned to four groups, shams as well as a CCI only, an HS only, and a CCI+HS groups. The CCI and HS reduced cerebral blood flow (CBF) in multiple regions of interest (ROIs) in the hemisphere ipsilateral and contralateral to injury. Hemorrhagic shock to a level of ∼30 mm Hg exacerbated the CCI-induced CBF reductions in multiple ROIs ipsilateral to injury (hemisphere and thalamus) and in the hemisphere contralateral to injury (hemisphere, thalamus, hippocampus, and cortex, all P</p>