10.1184/R1/6104021.v1
Kasturi Haldar
Kasturi
Haldar
Natalia Hiller
Natalia
Hiller
Christiaan van Ooij
Christiaan
van Ooij
Souvik Bhattacharjee
Souvik
Bhattacharjee
Plasmodium parasite proteins and the infected erythrocyte.
Carnegie Mellon University
2005
Animals
Erythrocytes
Humans
Malaria
Falciparum
Plasmodium falciparum
Protein Sorting Signals
Protein Transport
Protozoan Proteins
Severity of Illness Index
Vacuoles
2005-09-01 00:00:00
Journal contribution
https://kilthub.cmu.edu/articles/journal_contribution/Plasmodium_parasite_proteins_and_the_infected_erythrocyte_/6104021
<p>Erythrocyte modification by malaria proteins is linked to both disease severity and infection. In this issue of Trends in Parasitology, Templeton and Deitsch, and Horrocks and Muhia discuss recent work identifying a host-targeting (HT) signal on malaria proteins. This signal predicts a secretome of 300-400 effectors for the human malaria parasite Plasmodium falciparum, vastly expanding the number of potential vaccine and drug targets. The HT signal seems to be distinct from known cellular transport signals, which suggests that it might be a novel eukaryotic secretion signal.</p>