10.1184/R1/6104396.v1
Jason B. Castro
Jason
B. Castro
Nathan Urban
Nathan
Urban
Subthreshold glutamate release from mitral cell dendrites.
Carnegie Mellon University
2009
Animals
Newborn
Bicuculline
Biophysics
Calcium
Dendrites
Dose-Response Relationship
Drug
Drug Interactions
Electric Stimulation
Excitatory Amino Acid Antagonists
GABA Antagonists
Glutamic Acid
Inhibitory Postsynaptic Potentials
Membrane Potentials
Methoxyhydroxyphenylglycol
Mice
Olfactory Bulb
Patch-Clamp Techniques
Pyridazines
Receptors
Metabotropic Glutamate
Sensory Receptor Cells
2009-05-27 00:00:00
Journal contribution
https://kilthub.cmu.edu/articles/journal_contribution/Subthreshold_glutamate_release_from_mitral_cell_dendrites_/6104396
<p>The dendrites of a number of neuron types function as presynaptic structures, releasing transmitter after action potentials and dendritic spikes. In this regard, dendrites can function like axons, producing discrete outputs after suprathreshold electrical events. However, as the major site of synaptic inputs, dendrites experience ongoing subthreshold fluctuations in membrane potential, raising the question of whether these subthreshold changes can cause changes in transmitter release. Here, we show that mitral cells of the accessory olfactory bulb release glutamate from their dendrites in response to both subthreshold and suprathreshold stimuli. Whereas subthreshold output was typically low under control conditions, it could be enhanced several fold by pharmacological or endogenous activation of group I metabotropic glutamate receptors. These results indicate that presynaptic dendrites can support two distinct forms of output, and can dynamically regulate how electrical activity is coupled to transmitter release.</p>