10.1184/R1/6617666.v1 Cuneyt Alper Cuneyt Alper William J Doyle William J Doyle David P Skoner David P Skoner Craig A Buchman Craig A Buchman Sheldon Cohen Sheldon Cohen Jack M Gwaltney, Jr Jack M Gwaltney Prechallenge Antibodies Moderate Disease Expression in Adults Experimentally Exposed to Rhinovirus Strain Hanks Carnegie Mellon University 1998 psychology 1998-07-01 00:00:00 Journal contribution https://kilthub.cmu.edu/articles/journal_contribution/Prechallenge_Antibodies_Moderate_Disease_Expression_in_Adults_Experimentally_Exposed_to_Rhinovirus_Strain_Hanks/6617666 <p>This double-blind study determined the influence of serum neutralizing antibody titers on the rate of infection and magnitude of disease expression after experimental exposure of adult volunteers to rhinovirus strain Hanks (RV-H). A total of 133 healthy volunteers were tested for antibody status, cloistered for a 6-day period, and challenged with RV-H at the end of the first cloister day. On these days, response to viral challenge is assessed with symptom diaries and physical examinations. The low-titer infected group was significantly different from the intermediate-titer infected and the uninfected groups in terms of postchallenge nasal and throat symptoms, expelled secretion weights, nasal mucociliary clearance rates, and frequency of negative middle ear pressures. A similar trend held for the infected high-titer vs. low-titer group comparisons. These data show that high homotypic serum neutralizing antibody titers are associated with protection from infection and lessened signs and symptoms following experimental RV-H exposure.</p>