Carnegie Mellon University
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A domain-knowledge-inspired mathematical framework for the description and classification of H&E stained histopathology images.

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posted on 2011-10-19, 00:00 authored by Melody L. Massar, Ramamurthy Bhagavatula, John A. Ozolek, Carlos A. Castro, Matthew Fickus, Jelena KovacevicJelena Kovacevic

We present the current state of our work on a mathematical framework for identification and delineation of histopathology images-local histograms and occlusion models. Local histograms are histograms computed over defined spatial neighborhoods whose purpose is to characterize an image locally. This unit of description is augmented by our occlusion models that describe a methodology for image formation. In the context of this image formation model, the power of local histograms with respect to appropriate families of images will be shown through various proved statements about expected performance. We conclude by presenting a preliminary study to demonstrate the power of the framework in the context of histopathology image classification tasks that, while differing greatly in application, both originate from what is considered an appropriate class of images for this framework.

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Copyright 2011 Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. The version of record is available online at http://dx.doi.org/10.1117/12.893641

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2011-10-19

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