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Pulsatile microvascular cerebral blood flow waveforms change with intracranial compliance and age

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posted on 2024-01-08, 20:02 authored by Nikita Kedia, Michael M. McDowell, Jason YangJason Yang, Jingyi WuJingyi Wu, Robert M. Friedlander, Jana KainerstorferJana Kainerstorfer

Diffuse correlation spectroscopy (DCS) is an optical method to mea- sure relative changes in cerebral blood flow (rCBF) in the microvasculature. Each heartbeat generates a pulsatile signal with distinct morphological features that we hypothesized to be related to intracranial compliance (ICC).


We aim to study how three features of the pulsatile rCBF waveforms: the augmentation index (AIx), the pulsatility index, and the area under the curve, change with respect to ICC. We describe ICC as a combination of vascular compliance and extravascular compliance.


Our results suggest that the AIx measured in the cerebral micro-vasculature using DCS may be correlated to changes in ICC.

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