Figure S1. NIRS experimental measurements from prefrontal cortex of patients with and without SCD-directed therapies.

<p dir="ltr"><b>Figure S1. NIRS experimental measurements from prefrontal cortex of patients with and without SCD-directed therapies.</b> (A) phase differences between D and O, Arg(D)-Arg(O), (B) amplitude ratio, |D|/|O|, (C) phase differences between O and T, Arg(O)-Arg(T), and (D) amplitude ratio, |O|/|T|, of the NIRS experimental measurements in patients without an SCD intervention (n=6, sex=50% male, blue), and patients with an SCD intervention (n=5, sex= 80% male, light blue), and healthy controls (n= 14, sex=57% male, grey). Values marked with an asterisk refer to a p-value of the Wilcoxon signed tanked tests (p<0.05). The data shown represented the group average and averaged across both optical probe locations and are expressed as combined half-violin plots and box-and-whiskers plots (median, boxes denote interquartile range).</p><p dir="ltr">This item contains figural material referenced by the paper "Assessment of Cerebral Autoregulation and Cerebral Perfusion in Patients with Sickle Cell Disease using Frequency-Domain Near-Infrared Spectroscopy."</p>