Figure S3. Mathematical hemodynamic model and experimental NIRS measurements from the prefrontal cortex

<p dir="ltr"><b>Figure S3. Mathematical hemodynamic model and experimental NIRS measurements from the prefrontal cortex</b> for all patients with SCD (n=13, sex = 69% male, blue, circle) and healthy controls (n=14, sex = 57% male, grey, diamond) during a paced breathing paradigm in participant groups. (A) Phase differences between D and O, Arg(D)-Arg(O), (B) amplitude ratio |D|/|O|, (C) phase differences between O and T, Arg(O)-Arg(T), and (D) amplitude ratio |O|/|T|. The shaded blue and grey areas indicate the range of NIRS measurement values that correspond to the mathematical hemodynamic model that fall within the averaged error bars in Figure 4 and the acceptable solutions that met the fitting criteria.</p><p dir="ltr">This item contains figural material referenced by the paper "Assessment of Cerebral Autoregulation and Cerebral Perfusion in Patients with Sickle Cell Disease using Frequency-Domain Near-Infrared Spectroscopy."</p>