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Altered Topology of Neural Circuits in Congenital Prosopagnosia

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posted on 21.08.2017 by Gideon Rosenthal, Michal Tanzer, Erez Simony, Uri Hasson, Marlene Behrmann, Galia Avidan
Using a novel, fMRI-based inter-subject functional correlation (ISFC) approach, which isolates stimulus-locked inter-regional correlation patterns, we compared the cortical topology of the neural circuit for face processing in participants with an impairment in face recognition, congenital prosopagnosia (CP), and matched controls. Whereas the anterior temporal lobe served as the major network hub for face processing in controls, this was not the case for the CPs. Instead, this group evinced hyper-connectivity in posterior regions of the visual cortex, mostly associated with the lateral occipital and the inferior temporal cortices. Moreover, the extent of this hyper-connectivity was correlated with the face recognition deficit. These results offer new insights into the perturbed cortical topology in CP, which may serve as the underlying neural basis of the behavioral deficits typical of this disorder. The approach adopted here has the potential to uncover altered topologies in other neurodevelopmental disorders, as well.

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This work was supported by ISF grant 296/15 to GA and NSF grants BCS-1354350 and #SBE-0542013 to MB.

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This is the published PDF version of, "Rosenthal, G., Tanzer, M., Simony, E., Hasson, U., Behrmann, M., & Avidan, G. (2017). Altered topology of neural circuits in congenital prosopagnosia. eLife, 6, e25069. http://doi.org/10.7554/eLife.25069."

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21/08/2017

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