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Coarse-grained modeling of interactions of lipid bilayers with supports

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posted on 2008-11-01, 00:00 authored by Matthew I. Hoopes, Markus DesernoMarkus Deserno, Margie L. Longo, Roland Faller

We characterize the differences between supported and unsupported lipid bilayer membranes using a mesoscopic simulation model and a simple particle-based realization for a flat support on to which the lipids are adsorbed. We show that the nanometer roughness of the support affects membrane binding strength very little. We then compare the lipid distributions and pressure profiles of free and supported membranes. The surface localization of the proximal leaflet breaks the symmetry seen in a free bilayer, and we quantify the entropic penalty for binding and the increased lateral compression modulus.

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2008-11-01

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