<p>Biofilms are a principal form of microbial growth and are critical to development of clinical infection. They are responsible for a broad spectrum of microbial infections in the human host. Many medically important fungi produce biofilms, including <em>Candida</em> <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1002585#ppat.1002585-Finkel1">[1]</a>, <em>Aspergillus</em> <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1002585#ppat.1002585-Beauvais1">[2]</a>,<em>Cryptococcus</em> <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1002585#ppat.1002585-Martinez1">[3]</a>, <em>Trichosporon</em> <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1002585#ppat.1002585-DiBonaventura1">[4]</a>, <em>Coccidioides</em> <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1002585#ppat.1002585-Davis1">[5]</a>, and <em>Pneumocystis</em> <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1002585#ppat.1002585-Cushion1">[6]</a>. In this review we emphasize common features among fungal biofilms, and point toward genes and pathways that may have conserved roles.</p>