Biofilms are a principal form of microbial growth and are critical to development of clinical infection. They are responsible for a broad spectrum of microbial infections in the human host. Many medically important fungi produce biofilms, including Candida[1], Aspergillus[2],Cryptococcus[3], Trichosporon[4], Coccidioides[5], and Pneumocystis[6]. In this review we emphasize common features among fungal biofilms, and point toward genes and pathways that may have conserved roles.