Carnegie Mellon University
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Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes.

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journal contribution
posted on 2011-08-14, 00:00 authored by Subhadeep Roy, Kimberly J. Zanotti, Connor T. Murphy, Farial A. Tanious, W. David Wilson, Danith LyDanith Ly, Bruce ArmitageBruce Armitage

Guanine-rich peptide nucleic acid probes hybridize to DNA G quadruplex targets with high affinity, forming PNA-DNA heteroquadruplexes. We report a surprising degree of kinetic discrimination for PNA heteroquadruplex formation with a series of DNA targets. The fastest hybridization is observed for targets folded into parallel morphologies.


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