Reduced Structural Connectivity in Ventral Visual Cortex in Congenital Prosopagnosia

Using diffusion tensor imaging and tractography, we found that a disruption in structural connectivity in ventral occipitotemporal cortex may be the neurobiological basis for the lifelong impairment in face recognition that is experienced by individuals who suffer from congenital prosopagnosia. Our findings suggest that white-matter fibers in ventral occipitotemporal cortex support the integrated function of a distributed cortical network that subserves normal face processing.