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Telomeric SUMO level influences the choices of APB formation pathways and ALT efficiency

journal contribution
posted on 2025-11-21, 18:09 authored by Rongwei Zhao, Xiaoyang Yu, Tafadzwa Chigumira, Meng Xu, Allison Wivagg, Rachel M. Lackner, Jayme Salsman, Graham Dellaire, Michael J Matunis, David M. Chenoweth, Xiaolan Zhao, Huaiying Zhang
<p dir="ltr">This journal contribution is published Open Access by the publisher. Follow the DOI link to retrieve a copy of the full text. </p><p dir="ltr">We thank Dr. Roger A. Greenberg (Department of Cancer Biology, Penn Center for Genome Integrity, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA), Dr. Eros Lazzerini Denchi (Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA), Dr. Michael J Matunis (Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA), Dr. Michael Rosen (Department of Biophysics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA), Dr. Karsten Rippe (German Cancer Research Center (DKFZ) Heidelberg, Division of Chromatin Networks, Heidelberg, Germany), Dr. Roderick J. O’Sullivan (Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA), Dr. Jaewon Min (Institute for Cancer Genetics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA), Eugene V. Makeyev (Center for Developmental Biology, King’s College London, London, UK), and Dr. Hung-Ying Kao (Departments of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH, USA) for kindly gifting plasmids and cell lines.,This work was supported by the United States National Institutes of Health Grant U01CA260851 to Huaiying Zhang, GM118510 to David M. Chenoweth, R35 GM145260 to Xiaolan Zhao, GM060980 to Michael J. Matunis, and a Project Grant from the Canadian Institutes of Health Research PJT-156017 to Graham Dellaire.,Author contributions: Rongwei Zhao: conceptualization, data curation, formal analysis, investigation, methodology, project administration, resources, validation, visualization, and writing—original draft, review, and editing. Xiaoyang Yu: formal analysis, investigation, methodology, validation, visualization, and writing—review and editing. Tafadzwa Chigumira: formal analysis and investigation. Meng Xu: investigation. Allison Wivagg: data curation. Rachel M. Lackner: methodology. Jayme Salsman: methodology and resources. Graham Dellaire: resources and writing—review and editing. Michael J. Matunis: resources and writing—review and editing. David M. Chenoweth: methodology, resources, supervision, validation, and writing—review and editing. Xiaolan Zhao: conceptualization, funding acquisition, project administration, visualization, and writing—original draft, review, and editing. Huaiying Zhang: conceptualization, funding acquisition, project administration, resources, supervision, visualization, and writing—original draft, review, and editing.</p>

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