Exploring the Microbiome-Neuromuscular Axis in C.elegans Parkinson's Disease Models
Parkinson's disease (PD) is a debilitating neurodegenerative disorder that affects millions of people worldwide. Recent research suggests that changes in the microbiome may play a role in PD development and progression. In this study, we aimed to identify bacteria and associated small-molecule compounds that can improve the neuromuscular deficiencies of C. elegans PD models by influencing their microbiome. To accomplish this, we developed a high-throughput pipeline for assessing the impact of a bacterial diet on C. elegans PD model thrash counts as a measure of movement improvement in neuromuscular deficiency. Our pipeline incorporates automating video recording in the lab, an algorithm for measuring thrash counts, a suggested method for feature representation of bacteria and a predictive model which enable mass-screening for potential treatments. Our research has the potential to significantly impact the search for PD treatments by providing valuable insights into the characteristics and effectiveness of potential therapies.
History
Date
2023-05-02Academic Program
- Computational Biology