Unveiling non-synonymous SNP Effects on Periodontitis: An In-silico Exploration

Periodontitis is a severe gum disease leading to tooth loss and it can be influenced by Single Nucleotide Polymorphisms (SNPs) which are small-scale genetic mutations occurring with one base. Our study investigated Periodontitis-associated SNPs sourced from 9 studies, using sequence-based tools. We analyzed 3D structures of genes corresponding to these SNPs, evaluating protein stability and docking interactions. Four SNPs were found to destabilize genes, impacting interactions with associated proteins and worsening Periodontitis. OBP2A, NOD2, PSD4, and OR11H6 were the genes identified and their SNPs were predicted as pathogenic, potentially serving as susceptibility markers for Periodontitis diagnosis. However, further in-vitro research is necessary to confirm these findings, providing broader insights into genetic susceptibility to Periodontitis.