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thesis
posted on 2014-08-01, 00:00 authored by Brian D. HoltNanostructured materials are hailed to be the solutions of the future for many research areas, and single wall carbon nanotubes (SWCNTs) are one of the more interesting materials due to their highly desirable electronic, optical, thermal
and mechanical properties. For instance, this combination of properties is of wide interest for biological applications, including cellular technologies. However,
understanding cellular processing of SWCNTs is limited. In this thesis, quantification of sub-cellular events–including SWCNT uptake rates, altered mitosis, redistribution of sub-cellular components and reduced cellular functionalities–is used to formulate insight into how cells internalize and process
SWCNTs. By understanding sub-cellular processing of SWCNTs, new basic science endeavors and SWCNT-based biological applications can be more effectively developed, and the insights can be generalized to other nanostructured materials.
History
Date
2014-08-01Degree Type
- Dissertation
Department
- Biomedical Engineering
Degree Name
- Doctor of Philosophy (PhD)