Revealing the Structural and Molecular Basis of Retroviral Assembly and Endolysin PlyC Membrane Translocation Using Surface Plasmon Resonance and Neutron Reflectometry

In this thesis we focus on the mechanistic understanding of two membrane mediated biological processes: retroviral assembly and endolysin PlyC plasma membrane translocation. Retroviral Gag polyprotein is the structural determinant that assembles in a protein lattice on the hosts plasma membrane to trigger formation of the viral protein/membrane shell.