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Spike Train Correlation in Random Walk Integrate and Fire Neurons

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thesis
posted on 29.04.2014, 00:00 by Jonathan W. Yu

One way to analyze how our brains function is to apply statistical models to neural data. In 1998, Shadlen and Newsome observed that a balanced random walk integrateand-fire model can model experimental data such as single-unit recordings of rhesus monkeys. Using this model, I study the spike count correlation of two neurons under varying conditions. Through simulations, I look at the relationship of spike count correlation across two neurons to firing input rate when the inputs are independent and correlated. After this step, I look at whether an oscillatory input affects synchrony, i.e., synchronous firing of two neurons in close temporal proximity. It is crucial to understand what affects synchrony as a little change in synchrony can cause huge impacts in cellular processes in the brain and in how neurons communicate with each other.

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29/04/2014

Advisor(s)

Robert Kass

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