This README.txt file was generated on 20190407 by Adnan Hirad ------------------- GENERAL INFORMATION ------------------- 1. Title of Dataset: A common neural signature of brain injury in concussion and sub-concussion 2. Author Information First Author Contact Information Name: Adnan A. Hirad Institution: University of Rochester School of Medicine and Dentistry Address: 601 Elmwood Ave, Rochester, NY 14642 Email: adnan_hirad@urmc.rochester.edu Second Author Contact Information Name: Jeffrey J. Bazarian Institution: University of Rochester School of Medicine and Dentistry Address: 601 Elmwood Ave, Rochester, NY 14642 Email: jeff_bazarian@urmc.rochester.edu Third Author Contact Information Name: Kian Merchant-Borna Institution: University of Rochester School of Medicine and Dentistry Address: 601 Elmwood Ave, Rochester, NY 14642 Email: Kian_Merchant-Borna@urmc.rochester.edu Fourth Author Contact Information Name: Frank E. Garcea Institution: Moss Rehabilitation Research Institute Address: Elkins Park, PA Email: garceafr@einstein.edu Fifth Author Contact Information Name: Sarah Heilbronner Institution: Department of Neuroscience, University of Minnesota Address: Email: sarah.heilbronner@gmail.com Sixth Author Contact Information Name: David Paul Institution: University of Rochester School of Medicine and Dentistry Address: 601 Elmwood Ave, Rochester, NY 146427 Email: David_Paul@urmc.rochester.edu Seventh Author Contact Information Name: Eric B. Hintz Institution: Division of Neurosurgery, San Antonio Military Medical Center, San Antonio TX Address: Email: ebhintz@gmail.com Eighth Author Contact Information Name: Edwin van Wijngaarden Institution: University of Rochester School of Medicine and Dentistry Address: 601 Elmwood Ave, Rochester, NY 14642 Email: Edwin_van_Wijngaarden@urmc.rochester.edu Nineth Author Contact Information Name: Giovanni Schifitto Institution: University of Rochester School of Medicine and Dentistry Address: 601 Elmwood Ave, Rochester, NY 14642 Email: Giovanni_Schifitto@urmc.Rochester.edu Tenth Author Contact Information Name: David W. Wright Institution: Emory University School of Medicine Address: Email: david.wright@emory.edu Eleventh Author Contact Information Name: Tamara Espinoza Institution: Emory University School of Medicine Address: tamara.espinoza@emory.edu Email: Corresponding Author Contact Information Name: Bradford Z. Mahon Institution: Carnegie Mellon University Address: 5000 Forbes Ave, Pittsburgh, PA 15213 Email: bmahon@andrew.cmu.edu 3. Date of data collection: 2011-2013 4. Geographic location of data collection: Rochester, NY, USA 5. This study was supported by funds from the National Football League Charities https://www- nflcharities-org.ezpminer.urmc.rochester.edu/ and NIH K24 HD064754 to JJB, National Institute of Nursing Research Intramural Research Program, US Army Rapid Innovation Fund (W911NF- 11-R-0017) to DWW, NIH grant R01 MH099921 to GS, and NIH Grants R21NS076176, R01NS089609, and R01EY028535 to BZM. Support for AH was provided by the University of Rochester UL1 TR002001 via the NIH/National Center for Advancing Translational Sciences, BWF-IIMP Pilot Project, as well as a predoctoral training grant to the Clinical & Translational Sciences Institute (TL1 TR002000). FEG was supported by a University of Rochester Center for Visual Science predoctoral training fellowship (NIH Training Grant 5T32EY007125-24) and a Moss Rehabilitation Research Institute postdoctoral training fellowship (NIH T32HD007425). SH was supported, in part, by NIH grant R01MH118257. The funders had no role in study design, data collection, data analysis, decision to publish, or preparation of the manuscript. -------------------------- SHARING/ACCESS INFORMATION -------------------------- 1. Licenses/restrictions placed on the data: CC by 4.0 2. DOI: 10.1184/R1/7964984 3. For data usage please cite as follows: Adnan A. Hirad, Jeffrey J. Bazarian, Kian Merchant-Borna, Frank E. Garcea, Sarah Heilbronner, David Paul, Eric B. Hintz, Edwin van Wijngaarden, Giovanni Schifitto, David W. Wright, Tamara Espinoza, Bradford Z. Mahon. A common neural signature of brain injury in concussion and sub-concussion. DOI. # --------------------- DATA & FILE OVERVIEW --------------------- G. Filename: sb_X-Y.zip Short description: BIDS format MRI data collected in for each subject (X) and subject category (control vs experiment) (Y) dwi folder contains diffusion weighted scan. fmap folder field map scans for correcting inhomogeneities in DTI data. Anat folder contains T1 weighted scans. ---------------------------------------------- DATA DESCRIPTION FOR: BIDS_sub_summary.xlsx ---------------------------------------------- This file contains the subject ID (Sub) corresponding to the zip file sub-X-Y.zip that contains all MRI data collected for that subject at that session (Ses). ------------------------------------- DATA DESCRIPTION FOR: sub-X_ses-Y.zip ------------------------------------- Repetitive Sub-Concussive Head Impacts (RSHI) cohort. Participants were 42 male football players on the University of Rochester football team (NCAA division-III), enrolled over the course of 3 seasons (2011, 2012, 2013). Three subjects were lost to follow-up and 1 subject lacked field map correction scans, yielding 38 complete datasets (mean age = 19.8, median = 20). All of the players sustained repetitive head impacts across the season, but only 2 of the 38 sustained clinically defined concussion/mTBI.For all participants in the RSHI cohort, MRI scanning was carried out 2 weeks prior to the start of the season and within 1 week after completion of the season. In order to record the inertial loading sustained by the players’ brains throughout the season of play, each player wore a helmet-mounted accelerometer that measured linear and rotational acceleration throughout all practices and games. These files contain all of the MRI data (in BIDS format v1.0.1) acquired for a given subject (sub-X) during a given session (ses-Y). File naming convention follows the brain imaging data structure (BIDS) format (Gorgolewski et al., 2016) The csv file named sub-X_ses-Y_scans.tsv lists all of the scans contained within the sub-X_ses-Y.zip file. Subfolders: 1. dwi nifti file containing the diffusion weighted scan data json file containing scanner parameters 2. fmap nifti file containing of magnitude and phase of field map json files containing scanner parameters 3. anat nifti file containing T1 weighted scan data (and T2 FLAIR scan data for clinical sessions) json file containing scanner parameters -------------------------- METHODOLOGICAL INFORMATION -------------------------- 1. Software-specific information: Generic software Name: MATLAB Version: 2015b Product URL: https://www.mathworks.com/products/matlab.html Software for data analysis Name: FSL Version: fsl-5.0.9 Product URL: https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/FSL Name: Freesurfer Version: freesurfer-Darwin-OSX-stable-pub-v6.0.0-2beb96c Product URL: http://surfer.nmr.mgh.harvard.edu 2. Equipment-specific information: MRI Manufacturer: Seimens Model: Trim Trio (3T) Head coil: 12 channel