Neural Dynamics and Interactions in the Human Ventral Visual Pathway
thesisposted on 2018-12-21, 00:00 authored by Yuanning LiYuanning Li
The ventral visual pathway in the brain plays central role in visual object recog-
nition. The classical model of the ventral visual pathway, which poses it as a hierarchical, distributed and feed-forward network, does not match the actual structure of the pathway, which is highly interconnected with reciprocal and non-hierarchical projections. Here we address three major consequences of this non-classical structure with regard to neural dynamics and interactions: (i) the model does not consider any extended information processing dynamics; (ii) the model does not allow for adaptive and recurrent interactions between areas; (iii) the model only character-
izes evoked-response with no state-dependence from the neural context. To begin
to address these gaps in the classical model, we focus on the categorical-selective
regions in the ventral pathway and study the neural dynamics and interactions using intracranial electroencephalography (iEEG), which overcomes the limitations of
spatiotemporal resolution in current non-invasive human neuroimaging techniques.
With respect to the first consequence, we applied multivariate pattern analysis
(MVPA) methods to the iEEG signal to analyze the dynamic roles of the word and face sensitive areas. We found that both areas demonstrated a similar multi-stage information processing dynamic wherein the representation in category-selective fusiform gyrus evolves from a gist category-level and similarity-based representation to an invariant and highly detailed individual representation over the course of
500 ms. In addition, our results also suggest a dissociation between structural and motion in the face processing streams.
Regarding to the second consequence, we introduced a novel method termed
Multi-Connection Pattern Analysis (MCPA) to extract the discriminant information about cognitive states solely from the shared activity between neural populations from the interacting brain areas. Our results on iEEG and fMRI data with MCPA support the hypothesis that individual-level exemplar information is not only encoded by the population activity within certain brain populations, but also represented through recurrent interactions between multiple distributed populations at the
Finally, to address the third consequence, we designed a two-stage generalized linear model to study the relationship between category tuning and the ongoing neural activity in category selective cortical areas. We used this model to demonstrate
that endogenous activity modulates the category selective tuning in the post-stimulus evoked response, and the same aspects of endogenous activity that modulate tuning also predict perceptual behavior.
Taken together, in this thesis we develop and apply statistical methods to assess the properties of the non-classical structure in the ventral visual stream, and high-light contributions of regions to multiple stages of processing through interactive and
distributed computation that is influenced by ongoing neural context.
DepartmentCenter for the Neural Basis of Cognition
- Doctor of Philosophy (PhD)